Vaccination plans for people with weak immune systems need to be customized. This is because everyone has different needs. Here are some important points to consider:

1. Type of Immune Problem:

   • Some people have primary disorders, like X-linked agammaglobulinemia. This is rare, affecting about 1 in 200,000 people, and they usually need inactivated vaccines.
   • Others have secondary disorders, like HIV. In the U.S., there are about 1.1 million people with HIV. They may need a different schedule for vaccinations.

2. Type of Vaccine:

   • Live vaccines are typically not safe for those with weak immune systems, with a risk of about 1 in 200.
   • Inactivated vaccines are safer and are usually the best choice.

3. Timing and Dosage:

   • The timing of the vaccines should be based on how strong the person’s immune system is. For example, doctors look at certain numbers for HIV patients, like the CD4 count. Dosages may also change depending on how well the person responds to the vaccine.

4. Monitoring:

   • It’s important to regularly check antibody levels to see how well the vaccine is working. A normal response is usually more than a 1:10 titer.

By using these personalized vaccination strategies, we can help lower the risk of infections for people with weakened immune systems.