Neurons, which are the cells in our brain and nervous system, face some big challenges when they try to change their structure because of activity. Let’s break this down into simpler parts.

1. Structural Limitations:

   • Neurons have a strong and stiff structure. This makes it hard for them to change when they need to.
   • Dendritic spines are tiny parts of neurons that help them connect with each other. When there is a lot of activity, these spines might not grow as well as they should.

2. Energy Constraints:

   • When neurons are more active, they need more energy. This can push their limits and make them less efficient.

3. Potential Solutions:

   • Looking into neurotrophic factors (these help neurons grow) might show us ways to encourage dendritic growth.
   • Using special stimulation techniques can boost the connections between neurons without putting too much stress on them.

Finding ways to overcome these challenges is really important. It helps neurons adapt and work better.