Genetic differences in patients can really change how drugs work in the body. Here are a few ways that happens:
Enzyme Activity: Some people have different versions of enzymes called cytochrome P450. These enzymes help break down medications. For example, a person with a special version of the CYP2D6 enzyme might process drugs like codeine in a different way. This can affect how well the drug works and can also increase the risk of side effects.
Transport Proteins: There are also proteins in our bodies that help move drugs around. Differences in these proteins, like P-glycoprotein, can change how a drug is absorbed and distributed. If these proteins work differently, it might lead to too much of a drug in the system, which can cause problems.
Receptor Differences: Changes in genes that make drug receptors can impact how the body responds to medications. This can affect how drugs interact and work together inside the body.
Knowing about these genetic factors is really important for making medicine more personalized and effective for everyone!
Genetic differences in patients can really change how drugs work in the body. Here are a few ways that happens:
Enzyme Activity: Some people have different versions of enzymes called cytochrome P450. These enzymes help break down medications. For example, a person with a special version of the CYP2D6 enzyme might process drugs like codeine in a different way. This can affect how well the drug works and can also increase the risk of side effects.
Transport Proteins: There are also proteins in our bodies that help move drugs around. Differences in these proteins, like P-glycoprotein, can change how a drug is absorbed and distributed. If these proteins work differently, it might lead to too much of a drug in the system, which can cause problems.
Receptor Differences: Changes in genes that make drug receptors can impact how the body responds to medications. This can affect how drugs interact and work together inside the body.
Knowing about these genetic factors is really important for making medicine more personalized and effective for everyone!