Understanding the different types of immunoglobulins, which are proteins made by our immune system, can be tricky when diagnosing diseases. Here are some of the challenges:

1. Complex Immune Response: Different diseases can involve various types of immunoglobulins. This can make it hard to understand the results.

2. Cross-Reactivity: Sometimes, antibodies can attach to similar things in the body. This can lead to incorrect results, called false positives.

3. Limited Specificity: Tests for immunoglobulins might not point to just one specific disease.

Possible Solutions:

• Use advanced methods like ELISA and mass spectrometry to get more accurate results.
• Mix immunoglobulin testing with other medical information to improve diagnosis accuracy.