Setting up a Node.js development environment can be tricky. Many developers feel frustrated because there are several important tools to deal with. Here are some challenges you might face:

1. Node.js and npm: Installing these tools looks easy, but you might run into problems like different versions not working together or issues with file paths. This can slow you down.

2. Code Editor: Lots of people like using Visual Studio Code, but getting it set up with the right add-ons can be a hassle. It often takes a lot of trying different things before you get it right.

3. Version Control (Git): Learning how to use Git can be tough. Fixing merge conflicts—when changes from different people clash—can be confusing. It’s important to get to know Git commands to avoid mistakes.

4. Debugger: Setting up a debugger can be complicated. Understanding how Node.js works inside can be needed to make it work well.

To tackle these problems, there are plenty of guides and community help available. They can really support developers when they're stuck.