ADME is really important in making medicine personal and helping patients. Let’s break down what each part means:
Drug Absorption: How much medicine gets into your body can change. Things like stomach acidity and how your enzymes work can affect this. About 20% of patients might absorb medicine differently, which can make a big difference in how well the medicine works.
Distribution: Everyone’s body is different. For example, the amount of fat in a person’s body can change how medicine spreads. Some types of medicine, called lipophilic drugs, can be found in different amounts in different people, with differences of about 30%.
Metabolism: Our genes can change how our bodies break down medicine. Some people, roughly 10%, don’t metabolize medicine well. This can cause too much medicine to build up, which can be harmful.
Excretion: How well our kidneys work affects how quickly we get rid of medicine. Many older patients, about 30%, may have some kidney problems, which can change how much medicine they need.
By understanding these ADME factors, doctors can create better treatment plans. This makes it easier for patients to follow their medicine routines and helps the medicines work better and safer.
ADME is really important in making medicine personal and helping patients. Let’s break down what each part means:
Drug Absorption: How much medicine gets into your body can change. Things like stomach acidity and how your enzymes work can affect this. About 20% of patients might absorb medicine differently, which can make a big difference in how well the medicine works.
Distribution: Everyone’s body is different. For example, the amount of fat in a person’s body can change how medicine spreads. Some types of medicine, called lipophilic drugs, can be found in different amounts in different people, with differences of about 30%.
Metabolism: Our genes can change how our bodies break down medicine. Some people, roughly 10%, don’t metabolize medicine well. This can cause too much medicine to build up, which can be harmful.
Excretion: How well our kidneys work affects how quickly we get rid of medicine. Many older patients, about 30%, may have some kidney problems, which can change how much medicine they need.
By understanding these ADME factors, doctors can create better treatment plans. This makes it easier for patients to follow their medicine routines and helps the medicines work better and safer.