The relationship between β-amyloid and tau proteins is important in understanding brain diseases. These proteins interact in ways that make it harder to find effective treatments. Here are some of the main challenges:

1. How They Work Together:

   • When β-amyloid builds up, it causes tau to change in a harmful way.
   • This leads to tau clumping together and forming tangles, which makes brain cells work worse.

2. Effects on Brain Cells:

   • Both β-amyloid and tau can weaken connections between brain cells and lead to cell death.

3. Treatment Challenges:

   • Right now, it’s tough for doctors to create treatments that can target both proteins at the same time.

To improve treatment options, researchers are looking into creating therapies that can address both β-amyloid and tau. This could help us take a more complete approach to treating these brain diseases.