When looking at Express.js and Django for university projects, there are some important differences to notice:

1. Language:

   • Express.js: This framework is built on Node.js and uses JavaScript.
   • Django: This one is based on Python and is really user-friendly.

2. Architecture:

   • Express.js: It is simple and flexible, which means you can set it up in many ways. It's great for making custom APIs (Application Programming Interfaces).
   • Django: It follows something called MTV (Model-Template-View) architecture. This helps you build things quickly because it has a built-in admin panel.

3. Learning Curve:

   • Express.js: If you already know JavaScript, this will be easier for you to learn.
   • Django: You’ll need to understand Python, which might be a bit more challenging at first.

For example, if you want to create a real-time chat app, Express.js gives you more ways to customize it. On the other hand, if you want to set up a blog quickly, Django can make that easier because it has many helpful features already included.