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What Are the Limitations of Michaelis-Menten Kinetics in Complex Biological Systems?

Michaelis-Menten kinetics is a way to understand how enzymes work. However, it has some problems when we look at complex biological systems. Here are two main issues:

  1. Steady-State Assumption: This model thinks that things stay the same, but that’s not always true in living systems where things change a lot.

  2. Single Substrate Focus: It usually only looks at one substance (called a substrate) at a time. This means it misses how different substances can interact with each other.

For example, in metabolic pathways, enzymes often work together. This teamwork can change how reactions happen. Plus, other factors like allosteric effects or feedback inhibition can make the reaction rates even more complicated. This means the basic model isn't always accurate in predicting what happens in these systems.

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Macromolecules for Medical BiochemistryEnzyme Kinetics for Medical BiochemistryMetabolism for Medical Biochemistry
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What Are the Limitations of Michaelis-Menten Kinetics in Complex Biological Systems?

Michaelis-Menten kinetics is a way to understand how enzymes work. However, it has some problems when we look at complex biological systems. Here are two main issues:

  1. Steady-State Assumption: This model thinks that things stay the same, but that’s not always true in living systems where things change a lot.

  2. Single Substrate Focus: It usually only looks at one substance (called a substrate) at a time. This means it misses how different substances can interact with each other.

For example, in metabolic pathways, enzymes often work together. This teamwork can change how reactions happen. Plus, other factors like allosteric effects or feedback inhibition can make the reaction rates even more complicated. This means the basic model isn't always accurate in predicting what happens in these systems.

Related articles