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What Are the Most Common Tumor Suppressor Gene Mutations Observed in Human Cancers?

Some of the most common changes in tumor suppressor genes that can lead to cancer are:

  • TP53: This gene often gets damaged in different types of cancer, like breast and lung cancer.

  • RB1: Changes in this gene are usually found in retinoblastoma, which is a type of eye cancer, and other tumors as well.

  • PTEN: Issues with this gene are linked to cancers such as breast, prostate, and endometrial cancer.

  • APC: This gene plays an important role in colorectal cancer, especially in a condition called familial adenomatous polyposis.

These changes stop cells from controlling their growth the way they should. This can lead to cells growing too much and becoming cancerous.

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General Pathology for Medical PathologySystems Pathology for Medical PathologyNeoplastic Pathology for Medical Pathology
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What Are the Most Common Tumor Suppressor Gene Mutations Observed in Human Cancers?

Some of the most common changes in tumor suppressor genes that can lead to cancer are:

  • TP53: This gene often gets damaged in different types of cancer, like breast and lung cancer.

  • RB1: Changes in this gene are usually found in retinoblastoma, which is a type of eye cancer, and other tumors as well.

  • PTEN: Issues with this gene are linked to cancers such as breast, prostate, and endometrial cancer.

  • APC: This gene plays an important role in colorectal cancer, especially in a condition called familial adenomatous polyposis.

These changes stop cells from controlling their growth the way they should. This can lead to cells growing too much and becoming cancerous.

Related articles