Genetic factors play a big role in primary immunodeficiency disorders (PIDs). These are conditions where inherited changes in our genes mess with how our immune system works. Because of this, people with PIDs are at a higher risk of getting infections.

Key Genetic Factors:

1. X-Linked Disorders:

   • One example is X-Linked Agammaglobulinemia. This happens because of changes in the BTK gene.
   • Because of these changes, the body doesn’t make enough B cells and antibodies, which are important for fighting off infections.

2. Autosomal Recessive Disorders:

   • An example is Severe Combined Immunodeficiency (SCID).
   • This condition can be caused by changes in the IL2RG gene. It affects both T cells and B cells, which are crucial for a healthy immune response.

3. Single Gene Mutations:

   • Sometimes, small changes in just one gene can lead to different types of immunodeficiency syndromes.
   • This shows how complex our genetics can be when it comes to how well our immune system works.

By understanding these genetic issues, doctors can better diagnose and treat people who are affected. This highlights just how important our genes are for keeping our immune health in check.