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What Role Does the Therapeutic Index Play in Drug Safety Evaluations?

The therapeutic index, or TI, is an important part of making sure drugs are safe to use. It tells us how safe a drug is by comparing the harmful dose to the helpful dose.

Here's the simple formula:

TI = TD50 / ED50

  • TD50 is the dose that causes harm to 50% of people.
  • ED50 is the dose that helps 50% of people.

When the TI is high, it means there's a bigger safety margin. This makes it easier for doctors to prescribe the drug without worrying too much about an overdose.

From my experience, knowing a drug's TI helps doctors make smart decisions. They can find the best ways to help patients while keeping risks low.

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Basics of Pharmacology for Medical PharmacologyTherapeutics for Medical PharmacologyClinical Pharmacology for Medical Pharmacology
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What Role Does the Therapeutic Index Play in Drug Safety Evaluations?

The therapeutic index, or TI, is an important part of making sure drugs are safe to use. It tells us how safe a drug is by comparing the harmful dose to the helpful dose.

Here's the simple formula:

TI = TD50 / ED50

  • TD50 is the dose that causes harm to 50% of people.
  • ED50 is the dose that helps 50% of people.

When the TI is high, it means there's a bigger safety margin. This makes it easier for doctors to prescribe the drug without worrying too much about an overdose.

From my experience, knowing a drug's TI helps doctors make smart decisions. They can find the best ways to help patients while keeping risks low.

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